Osamu Takeuchi Selected Research

Tretinoin (Retinoic Acid)

1/2010	LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
7/2008	Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.
1/2008	Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.
4/2007	TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
7/2006	Essential role of IPS-1 in innate immune responses against RNA viruses.
5/2006	Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.

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Osamu Takeuchi Research Topics

Disease

28	Inflammation (Inflammations) 01/2024 - 05/2002
27	Infections 01/2017 - 10/2002
19	Neoplasms (Cancer) 03/2024 - 02/2002
16	Virus Diseases (Viral Diseases) 01/2017 - 01/2004
10	Pancreatic Neoplasms (Pancreatic Cancer) 01/2024 - 11/2009
6	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2017 - 02/2006
6	Melanoma (Melanoma, Malignant) 01/2015 - 05/2006
5	Ulcerative Colitis 01/2023 - 10/2018
5	RNA Virus Infections 01/2010 - 07/2006
4	Fibrosis (Cirrhosis) 01/2021 - 12/2003
4	Sepsis (Septicemia) 10/2013 - 12/2004
3	Colitis 01/2023 - 11/2008
3	Hemorrhage 01/2022 - 05/2003
3	Bites and Stings (Sting) 01/2022 - 12/2009
3	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 01/2018
3	Immune System Diseases (Immune Disorders) 11/2021 - 01/2006
2	COVID-19 02/2024 - 11/2023
2	Leukopenia 01/2024 - 11/2021
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2023 - 11/2021
2	Shock 12/2022 - 11/2002
2	Bacterial Infections (Bacterial Infection) 12/2022 - 10/2014
2	Necrosis 02/2022 - 07/2004
2	Asthma (Bronchial Asthma) 01/2022 - 07/2011
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2022 - 12/2008
2	Adenocarcinoma 01/2019 - 04/2013
2	Hepatocellular Carcinoma (Hepatoma) 01/2018 - 02/2002
2	Neoplasm Metastasis (Metastasis) 01/2017 - 04/2013
2	Liver Cirrhosis (Hepatic Cirrhosis) 06/2012 - 12/2008
2	Granuloma 12/2009 - 03/2004
2	Nephritis 09/2009 - 12/2008
2	Malaria 01/2007 - 01/2005
2	Colonic Neoplasms (Colon Cancer) 12/2005 - 09/2005
2	Lewis Lung Carcinoma 02/2003 - 02/2002
1	Breast Neoplasms (Breast Cancer) 03/2024
1	Alopecia (Baldness) 01/2024
1	Sleep Bruxism 12/2023

Drug/Important Bio-Agent (IBA)

24	CytokinesIBA 11/2022 - 08/2002
16	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2017 - 10/2002
14	Proteins (Proteins, Gene)FDA Link 09/2023 - 05/2004
10	Messenger RNA (mRNA)IBA 10/2021 - 02/2002
9	Antiviral Agents (Antivirals)IBA 01/2015 - 01/2006
9	Interferon Type IIBA 03/2011 - 07/2005
8	Gemcitabine FDA Link 01/2024 - 11/2009
7	Interleukin-6 (Interleukin 6)IBA 01/2024 - 02/2002
7	InterferonsIBA 01/2021 - 06/2004
7	Pattern Recognition ReceptorsIBA 01/2017 - 03/2004
7	Phosphotransferases (Kinase)IBA 01/2015 - 06/2004
6	DNA (Deoxyribonucleic Acid)IBA 03/2024 - 01/2006
6	RNA (Ribonucleic Acid)IBA 01/2024 - 05/2006
6	LigandsIBA 01/2017 - 07/2004
6	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2010 - 05/2006
5	Antineoplastic Agents (Antineoplastics)IBA 01/2020 - 02/2002
5	LipopolysaccharidesIBA 01/2015 - 01/2004
5	Double-Stranded RNA (RNA, Double Stranded)IBA 06/2013 - 06/2004
5	Nucleic AcidsIBA 03/2011 - 01/2006
4	EndotoxinsIBA 05/2010 - 11/2002
4	Toll-Like Receptor 2IBA 09/2005 - 08/2002
3	1-phenyl-3,3-dimethyltriazene (PDT)IBA 11/2023 - 02/2022
3	Photosensitizing Agents (Photosensitizers)IBA 11/2023 - 02/2022
3	Viral RNAIBA 11/2023 - 04/2007
3	ChemokinesIBA 06/2023 - 05/2002
3	Ribonucleases (Ribonuclease)IBA 11/2022 - 04/2009
3	Transcription Factors (Transcription Factor)IBA 01/2021 - 10/2011
3	Checkpoint Kinase 1IBA 09/2020 - 06/2012
3	RNA-Binding Proteins (RNA-Binding Protein)IBA 06/2019 - 05/2015
3	Interleukin-12 (IL 12)IBA 02/2004 - 10/2002
2	2-mercaptopurineIBA 01/2024 - 11/2021
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2024 - 12/2008
2	Glycogen Synthase KinasesIBA 01/2024 - 12/2020
2	Mesalamine (Mesalazine)FDA LinkGeneric 01/2023 - 08/2021
2	SodiumIBA 10/2022 - 11/2008
2	TNF Receptor-Associated Factor 6 (TRAF6)IBA 01/2022 - 05/2009
2	EndoribonucleasesIBA 11/2021 - 10/2021
2	prexasertibIBA 09/2020 - 01/2020
2	Interleukin-4 (Interleukin 4)IBA 12/2017 - 09/2003
2	NLR ProteinsIBA 01/2017 - 03/2010
2	C-Type Lectins (C-Type Lectin)IBA 01/2017 - 03/2010
2	Irinotecan (Camptosar)FDA LinkGeneric 01/2015 - 11/2009
2	InflammasomesIBA 04/2014 - 11/2008
2	Interferon-gamma (Interferon, gamma)IBA 06/2012 - 02/2004
2	AntigensIBA 07/2011 - 05/2009
2	pristane (pristan)IBA 02/2011 - 12/2008
2	NF-kappa B (NF-kB)IBA 05/2010 - 07/2003
2	Antigen-Antibody Complex (Immune Complex)IBA 09/2009 - 12/2008
2	Poly I-CIBA 08/2009 - 01/2004
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 12/2008 - 12/2003
2	Interleukin-18 (Interleukin 18)IBA 11/2008 - 10/2002
2	RNA Helicases (RNA Helicase)IBA 07/2008 - 10/2005
2	hemozoinIBA 01/2007 - 01/2005
2	Complementary DNA (cDNA)IBA 09/2005 - 02/2002
1	NexusIBA 01/2024
1	poly(lactide) (polylactic acid)IBA 12/2023
1	AllergensIBA 06/2023

Therapy/Procedure

7	Therapeutics 01/2024 - 11/2009
3	Photochemotherapy (Photodynamic Therapy) 11/2023 - 02/2022
2	Drug Therapy (Chemotherapy) 12/2020 - 02/2002
2	Laparotomy 04/2013 - 03/2005
2	Immunotherapy 04/2008 - 02/2003
2	Hepatectomy 01/2008 - 05/2003
1	Hand Hygiene 02/2024